RESUMO
The cyanobacterial circadian clock has three relatively independent parts: the input path, the core oscillator, and the output path. The core oscillator is composed of three clock proteins: KaiA, KaiB, and KaiC. The interactions among these three proteins generate a rhythmic signal and convey the input signals to the output signals to maintain the accuracy and stability of the oscillation of downstream signals. Based on the cyanobacterial circadian clock and the structure, function, and interaction of the clock proteins of the core oscillator, combining the recent results from our laboratory, this review summarized the recent progresses of the molecular mechanism of KaiA in regulating KaiC's enzymatic activity, mediating phase reset of the oscillator, and competing with CikA for the binding site of KaiB.
Assuntos
Proteínas de Bactérias , Genética , Metabolismo , Relógios Circadianos , Genética , Peptídeos e Proteínas de Sinalização do Ritmo Circadiano , Metabolismo , Cianobactérias , Genética , Ativação Enzimática , GenéticaAssuntos
Humanos , Animais , Camundongos , Sono/fisiologia , Osso e Ossos/fisiologia , Ritmo Circadiano/fisiologia , Relógios Circadianos/fisiologia , Privação do Sono , Osteocalcina/metabolismo , Ritmo Circadiano/genética , Metaboloma/fisiologia , Peptídeos e Proteínas de Sinalização do Ritmo Circadiano/metabolismo , Relógios Circadianos/genéticaRESUMO
The history of the location of the University of Chile Faculty of Medicine North Campus is derived from a farm of Pedro de Valdivia founder of the city of Santiago de la Nueva Extremadura and governor of the Reyno de Chile. This work narrates succinctly the history of this particular location from the Spanish Conquest period to present days.